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KMID : 0861420120160020099
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Korean Journal of Nuclear Medicine Technology
2012 Volume.16 No. 2 p.99 ~ p.105
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The Preoperative Diagnosis of Thyroid Cancer in 18F-FDG PET/CT Dual Time Imaging of SUV and Evaluation of Radioactivity Measurement
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Lee Hyun-Kuk
Khang Hyun-Soo
Yang Seoun-Oh
Han Man-Seok
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Abstract
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Purpose:This study is designed to compare two parameters reflecting 18F-FDG uptake, SUV and radioactivity,
for diagnosis of thyroid cancer in dual time 18F-FDG PET/CT imaging and to find which parameter is more
useful to decide whether the tumor is malignant or not.
Materials and Methods:We performed retrospective
study for 40 patients. All patients are diagnosed as primary thyroid cancer and examined 18F-FDG PET/CT. First,
we got the dispersion of scattering beam of neck and lung apex to set a background and compared each
dispersion, mean value, standard deviation of maxSUV and radioactivity. Also, mean maxSUV, △maxSUV, △
maxBq/ml(%) and radioactivity between groups according to lesion’s size based on biopsy are compared with
independent-sample t-test.
Results: the values that were from maxSUV and radioactivity measurement
technique were compensated and calculated to practical values for mean comparison and patients were divided
to two groups based on tumor size, Group1 (size≤1 cm, n=21), Group2 (size>1 cm, n=19) for accurate
comparison. In Group1, maxSUV (semi-quantitative analysis) was increased from 5.64±5.85 (1.89~17.84) at
first image to 5.90±5.01 (1.95~18.22) at second image and radioactivity (Bq/ml) (quantitative analysis) showed
similar increase from 5.93±6.38 (2.50~16.75) at first image to 6.01±5.25 (2.66~16.58) at second image. In
Group2, TFmaxSUV was 10.54±14.36 (2.54~33.89) in true first image, TSmaxSUV was 9.85±12.88
(2.62~26.20) in true second image separately. The maxSUV showed a significant difference in the mean
comparison between the two groups (p=0.035) But, mean radioactivity (Bq/ml) was 5.93±6.38 (4.81~40.99) in
true first image, 6.01±5.25 (4.51~36.93) in true second image and didn’t show a significant difference
statistically (p=0.126)
Conclusion: In diagnosis of thyroid tumor, SUV and radioactivity depending on 18F-FDG
uptake showed high similarity with coefficient of determination (R2=0.939) and malignant evaluation results
using dual time also showed similar aspect. Radioactivity for evaluation of malignant tumor didn’t show better
specificity or sensitivity than maxSUV
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KEYWORD
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18F-FDG PET/CT , Dual Time Poin Image , maxSUV , Radioactivity
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